Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

DM2 CCTGCAGG repeats are crossover hotspots that are more prone to expansions than the DM1 CTGCAG repeats in Escherichia coli.

Journal of molecular biology - 30 Jun 2006

Dere Ruhee, Wells Robert D

Abstract excerpt

Myotonic dystrophy type 2 (DM2) is caused by the extreme expansion of the repeating tetranucleotide CCTG*CAGG sequence from <30 repeats in normal individuals to approximately 11,000 for the full mutation in certain patients. This repeat is in intron 1 of the zinc finger protein 9 gene on chromosome 3q21. Since prior work demonstrated that CTG*CAG and GAA*TTC triplet repeats (responsible for DM1 and Friedreich's...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Chromosomes, Human, Pair 3
Share to DNA Repair
Share to Myotonic Dystrophy

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Myotonin-Protein Kinase

Share to Protein Serine-Threonine Kinases

Share to Recombination, Genetic

Share to Thermodynamics

Share to Zinc Fingers

Source

Identifiers

PMID: 16753177
DOI: 10.1016/j.jmb.2006.05.012

Genes

GAA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

DM2 CCTG*CAGG repeats are crossover hotspots that are more prone to expansions than the DM1 CTG*CAG repeats in Escherichia coli.PMID 16753177Read ↗

The myotonic dystrophy type 1 triplet repeat sequence induces gross deletions and inversions.Semantic proximity Read ↗

DNA double-strand breaks induce deletion of CTG.CAG repeats in an orientation-dependent manner in Escherichia coli.Semantic proximity Read ↗

Massive contractions of Myotonic Dystrophy Type 2-associated CCTG tetranucleotide repeats occur via double strand break repair with distinct requirements for helicasesSemantic proximity Read ↗

Expansion of CTG repeats from human disease genes is dependent upon replication mechanisms in Escherichia coli: the effect of long patch mismatch repair revisited.Semantic proximity Read ↗

Genetic instabilities of (CCTG).(CAGG) and (ATTCT).(AGAAT) disease-associated repeats reveal multiple pathways for repeat deletion.Semantic proximity Read ↗

Imperfect hairpins formed by CTG trinucleotide repeats are heteroduplex DNA molecules in living cellsSemantic proximity Read ↗

Increased negative superhelical density in vivo enhances the genetic instability of triplet repeat sequences.Semantic proximity Read ↗

Roles of double-strand breaks, nicks, and gaps in stimulating deletions of CTG.CAG repeats by intramolecular DNA repair.Semantic proximity Read ↗

Mechanisms of DNA expansion.Semantic proximity Read ↗

Resection and repair of a Cas9 double-strand break at CTG trinucleotide repeats induces local and extensive chromosomal rearrangementsSemantic proximity Read ↗

TALEN-induced contraction of CTG trinucleotide repeats in myotonic dystrophy type 1 cellsSemantic proximity Read ↗

Mismatch repair in Escherichia coli enhances instability of (CTG)n triplet repeats from human hereditary diseases.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.