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Article

Sticky DNA formation in vivo alters the plasmid dimer/monomer ratio.

The Journal of biological chemistry - 20 Feb 2004

Vetcher Alexandre A, Wells Robert D

Abstract excerpt

Our discovery that plasmids containing the Friedreich's ataxia (FRDA) expanded GAA.TTC sequence, which forms sticky DNA, are prone to form dimers compared with monomers in vivo is the basis of an intracellular assay in Escherichia coli for this unusual DNA conformation. Sticky DNA is a single long GAA.GAA.TTC triplex formed in plasmids harboring a pair of long GAA.TTC repeat tracts in the direct repeat...

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Source

Identifiers

PMID: 14625291
DOI: 10.1074/jbc.M309595200

Genes

GAA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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