Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Unusual structures are present in DNA fragments containing super-long Huntingtin CAG repeats.

PloS one - 11 Feb 2011

Duzdevich Daniel, Li Jinliang, Whang Jhoon, Takahashi Hirohide, Takeyasu Kunio, Dryden David T F, Morton A Jennifer, Edwardson J Michael

Abstract excerpt

BACKGROUND: In the R6/2 mouse model of Huntington's disease (HD), expansion of the CAG trinucleotide repeat length beyond about 300 repeats induces a novel phenotype associated with a reduction in transcription of the transgene. METHODOLOGY/PRINCIPAL FINDINGS: We analysed the structure of polymerase chain reaction (PCR)-generated DNA containing up to 585 CAG repeats using atomic force microscopy (AFM). As the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to DNA, Single-Stranded
Share to Huntingtin Protein

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Huntington Disease

Share to Inverted Repeat Sequences

Share to Microscopy, Atomic Force

Share to Nucleic Acid Conformation

Share to Site-Specific DNA-Methyltransferase (Adenine-Specific)

Share to Trinucleotide Repeats

Source

Open in PubMed Open full text

Identifiers

PMID: 21347256
DOI: 10.1371/journal.pone.0017119
PMCID: PMC3037965

Genes

AFM

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Unusual structures are present in DNA fragments containing super-long Huntingtin CAG repeats.PMID 21347256Read ↗

Molecular conformations and dynamics of nucleotide repeats associated with neurodegenerative diseases: double helices and CAG hairpin loopsSemantic proximity Read ↗

A slipped-CAG DNA-binding small molecule induces trinucleotide-repeat contractions in vivo.Semantic proximity Read ↗

Approaches to Sequence the HTT CAG Repeat Expansion and Quantify Repeat Length VariationSemantic proximity Read ↗

Imperfect hairpins formed by CTG trinucleotide repeats are heteroduplex DNA molecules in living cellsSemantic proximity Read ↗

Atomic resolution structure of CAG RNA repeats: structural insights and implications for the trinucleotide repeat expansion diseasesSemantic proximity Read ↗

CAG repeat lengths > or =335 attenuate the phenotype in the R6/2 Huntington's disease transgenic mouse.Semantic proximity Read ↗

Length-dependent structure formation in Friedreich ataxia (GAA)n{middle dot}(TTC)n repeats at neutral pHSemantic proximity Read ↗

Structural analysis of slipped-strand DNA (S-DNA) formed in (CTG)n. (CAG)n repeats from the myotonic dystrophy locus.Semantic proximity Read ↗

Increased negative superhelical density in vivo enhances the genetic instability of triplet repeat sequences.Semantic proximity Read ↗

RNA Gelation in Repeat Expansion DisordersSemantic proximity Read ↗

Three-dimensional chromatin interactions remain stable upon CAG/CTG repeat expansionSemantic proximity Read ↗

Large-scale contractions of Friedreich's ataxia GAA repeats in yeast occur during DNA replication due to their triplex-forming ability.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.