Article
Brain MRI abnormalities in schizophrenia: same genes or same environment?
Psychological medicine - 1 Oct 2005
Rijsdijk F V, van Haren N E M, Picchioni M M, McDonald C, Toulopoulou T, Hulshoff Pol H E, Kahn R S, Murray R, Sham P C
Abstract excerpt
BACKGROUND: Structural brain volume abnormalities are among the most extensively studied endophenotypes in schizophrenia. Bivariate genetic model fitting (adjusted to account for selection) was used to quantify the genetic relationship between schizophrenia and brain volumes and to estimate the heritability of these volumes. METHOD: We demonstrated by simulation that the adjusted genetic model produced unbiased...
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