Article
Uncommon occurrence of fluoroquinolone resistance-associated alterations in GyrA and ParC in clinical strains of Chlamydia trachomatis.
Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy - 1 Oct 2004
Yokoi Shigeaki, Yasuda Mitsuru, Ito Shin-ichi, Takahashi Yoshihito, Ishihara Satoshi, Deguchi Takashi, Maeda Shin-ichi, Kubota Yasuaki, Tamaki Masayoshi, Fukushi Hideto
Abstract excerpt
Twenty-three clinical strains of Chlamydia trachomatis were isolated from men with chlamydial nongonococcal urethritis and examined for the presence of fluoroquinolone resistance-associated alterations in GyrA and ParC. The minimum inhibitory concentrations (MICs) of fluoroquinolones, erythromycin, and tetracycline were determined for 6 of the 23 isolates. In 12 of the 23 isolates, a single amino-acid change was...
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