Article
Mutations in the gyrA and parC genes associated with fluoroquinolone resistance in clinical isolates of Citrobacter freundii.
FEMS microbiology letters - 15 Sept 1997
Nishino Y, Deguchi T, Yasuda M, Kawamura T, Nakano M, Kanematsu E, Ozeki S, Kawada Y
Abstract excerpt
We determined partial sequences of the gyrA and parC genes of Citrobacter freundii type strain, and then examined 38 C. freundii clinical strains isolated from patients with urinary tract infections for the association of alterations in GyrA and ParC with susceptibility to fluoroquinolones. Our r...
Topics
- Amino Acid Sequence
- Anti-Infective Agents
- Base Sequence
- Citrobacter freundii
- DNA Gyrase
- DNA Topoisomerase IV
- DNA Topoisomerases, Type II
- Drug Resistance, Microbial
- Fluoroquinolones
- Gene Amplification
- Genes, Bacterial
- Humans
- Molecular Sequence Data
- Mutation
- Urinary Tract Infections