Article
Alterations within the quinolone resistance-determining regions of GyrA and ParC of Neisseria gonorrhoeae isolated in the Far East and the United States.
International journal of antimicrobial agents - 1 Aug 1999
Trees D L, Sandul A L, Peto-Mesola V, Aplasca M R, Leng H B, Whittington W L, Knapp J S
Abstract excerpt
The genetic mutations within the quinolone resistance-determining regions (QRDRs) of gyrA and parC of 234 Neisseria gonorrhoeae strains isolated in the Far East and the United States, which exhibited either clinically significant ciprofloxacin resistance (CipR) or intermediate ciprofloxacin resistance (CipI) were characterized. A number of GyrA/ParC amino acid alteration patterns were identified, the most...
Topics
- DNA Gyrase
- DNA Topoisomerase IV
- DNA Topoisomerases, Type II
- Drug Resistance, Microbial
- Mutation
- Neisseria gonorrhoeae
- Polymerase Chain Reaction
- Species Specificity