Article
Comparison of full gyrA, gyrB, parC and parE gene sequences between all Ureaplasma parvum and Ureaplasma urealyticum serovars to separate true fluoroquinolone antibiotic resistance mutations from non-resistance polymorphism.
The Journal of antimicrobial chemotherapy - 1 Sept 2009
Beeton Michael L, Chalker Victoria J, Kotecha Sailesh, Spiller O Brad
Abstract excerpt
OBJECTIVES: To determine the role of amino acid substitutions in Ureaplasma GyrA, GyrB, ParC and ParE proteins in mediating fluoroquinolone resistance. METHODS: Nucleic acid sequences from gyrA, gyrB, parC and parE genes from all 14 Ureaplasma serovars were aligned. Full genome sequences for sero...
Topics
- Amino Acid Sequence
- Amino Acid Substitution
- Anti-Bacterial Agents
- Bacterial Proteins
- Cluster Analysis
- DNA Gyrase
- DNA Mutational Analysis
- DNA Topoisomerase IV
- DNA, Bacterial
- Drug Resistance, Bacterial
- Fluoroquinolones
- Genotype
- Humans
- Infant, Newborn