Article
Association of FAS and FAS ligand genes polymorphism and risk of systemic lupus erythematosus.
TheScientificWorldJournal - 1 Jan 2013
Moudi Bita, Salimi Saeedeh, Farajian Mashhadi Farzaneh, Sandoughi Mahnaz, Zakeri Zahra
Abstract excerpt
UNLABELLED: FAS/FASL pathway plays a critical role in maintaining peripheral immune tolerance; therefore, the apoptosis genes, Fas and Fas ligand (FasL), could be suitable candidate genes in human SLE susceptibility. MATERIALS AND METHODS: In this case-control study, 106 SLE patients and 149 sex, age, and ethnicity matched healthy controls were genotyped for the Fas A-670G and FasLC-844T polymorphisms by...
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