Article
Identify Non-mutational p53 Functional Deficiency in Human Cancers.
Genomics, proteomics & bioinformatics - 3 Dec 2024
Li Qianpeng, Zhang Yang, Luo Sicheng, Zhang Zhang, Oberg Ann L, Kozono David E, Lu Hua, Sarkaria Jann N, Ma Lina, Wang Liguo
Abstract excerpt
An accurate assessment of p53's functional statuses is critical for cancer genomic medicine. However, there is a significant challenge in identifying tumors with non-mutational p53 inactivation which is not detectable through DNA sequencing. These undetected cases are often misclassified as p53-normal, leading to inaccurate prognosis and downstream association analyses. To address this issue, we built the support...
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