Article
Identify Non-Mutational p53 Functional Deficiency in Human Cancers
2022-07-31
Abstract excerpt
An accurate assessment of TP53 ’s functional status is critical for cancer genomic medicine. However, there is a significant challenge in identifying tumors with non-mutational p53 inactivations that are not detectable through DNA sequencing. These undetected cases are often misclassified as p53-normal, leading to inaccurate prognosis and downstream association analyses. To address this issue, we build the suppor...
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Identifiers and source
- Literature Corpus work
- 14f876dc-2cdc-5c35-9deb-bea8fd253310
- DOI
- 10.1101/2022.07.28.501874