Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Clozapine-induced agranulocytosis and hereditary polymorphisms of clozapine metabolizing enzymes: no association with myeloperoxidase and cytochrome P4502D6.

Pharmacopsychiatry - 1 Nov 2000

Dettling M, Sachse C, Müller-Oerlinghausen B, Roots I, Brockmöller J, Rolfs A, Cascorbi I

Abstract excerpt

The pathomechanisms of most drug-induced agranulocytoses are unclear; however, there are some studies pointing to genetic determinants. Some drug-induced agranulocytoses such as clozapine-induced agranulocytosis (CA) may be regarded as an idiosyncratic drug reaction because of its preclinical and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aged
Share to Aged, 80 and over
Share to Antipsychotic Agents

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Clozapine

Share to Cytochrome P-450 CYP2D6

Share to Peroxidase

Share to Polymorphism, Genetic

Share to Schizophrenia

Source

Identifiers

PMID: 11147929
DOI: 10.1055/s-2000-8359

Genes

MPO

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-11147929-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Clozapine-induced agranulocytosis and hereditary polymorphisms of clozapine metabolizing enzymes: no association with myeloperoxidase and cytochrome P4502D6.PMID 11147929Read ↗

Clozapine-induced agranulocytosis and its genetic determinants.Semantic proximity Read ↗

Genetic risk factors for clozapine-induced neutropenia and agranulocytosis in a Dutch psychiatric population.Semantic proximity Read ↗

Further evidence of human leukocyte antigen-encoded susceptibility to clozapine-induced agranulocytosis independent of ancestry.Semantic proximity Read ↗

Pharmacogenomics of Clozapine-induced agranulocytosis: a systematic review and meta-analysis.Semantic proximity Read ↗

NQO2 gene is associated with clozapine-induced agranulocytosis.Semantic proximity Read ↗

Drug-induced agranulocytosis: impact of different fcgamma receptor polymorphisms?Semantic proximity Read ↗

Clozapine-induced agranulocytosis in schizophrenic Caucasians: confirming clues for associations with human leukocyte class I and II antigens.Semantic proximity Read ↗

[Clozapine-induced agranulocytosis: genetic risk factors and an immunologic explanatory model].Semantic proximity Read ↗

Genetic determinants of drug-induced agranulocytosis: potential risk of olanzapine?Semantic proximity Read ↗

Establishing the characteristics of an effective pharmacogenetic test for clozapine-induced agranulocytosis.Semantic proximity Read ↗

Clozapine Pharmacogenetic Studies in Schizophrenia: Efficacy and AgranulocytosisSemantic proximity Read ↗

Relation of the Allelic Variants of Multidrug Resistance Gene to Agranulocytosis Associated With Clozapine.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.