Article
Structural peptides of a nonenveloped virus are involved in assembly and membrane translocation.
Journal of virology - 1 Oct 2005
Chevalier Christophe, Galloux Marie, Pous Joan, Henry Céline, Denis Jérôme, Da Costa Bruno, Navaza Jorge, Lepault Jean, Delmas Bernard
Abstract excerpt
The capsid of infectious bursal disease virus (IBDV), a nonenveloped virus of the family Birnaviridae, has a T=13l icosahedral shell constituted by a single protein, VP2, and several disordered peptides, all derived from the precursor pVP2. In this study, we show that two of the peptides, pep11 and pep46, control virus assembly and cell entry. Deletion of pep11 or even simple substitution of most of its residues...
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