Article
Structural polymorphism of the major capsid protein of a double-stranded RNA virus: an amphipathic alpha helix as a molecular switch.
Structure (London, England : 1993) - 1 Jul 2005
Saugar Irene, Luque Daniel, Oña Ana, Rodríguez José F, Carrascosa José L, Trus Benes L, Castón José R
Abstract excerpt
The infectious bursal disease virus T=13 viral particle is composed of two major proteins, VP2 and VP3. Here, we show that the molecular basis of the conformational flexibility of the major capsid protein precursor, pVP2, is an amphipatic alpha helix formed by the sequence GFKDIIRAIR. VP2 containing this alpha helix is able to assemble into the T=13 capsid only when expressed as a chimeric protein with an...
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