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Article

The role of Polo-like kinase 1 in the inhibition of centrosome separation after ionizing radiation.

The Journal of biological chemistry - 30 Dec 2005

Zhang Wei, Fletcher Lynda, Muschel Ruth J

Abstract excerpt

Activation of the G2/M cell cycle checkpoint by DNA damage prevents cells from entering mitosis. Centrosome separation is initiated in G2 phase and completed in M phase. This critical process for cell division is targeted by G2/M checkpoint. Here we show that Plk1 signaling plays an important role in regulation of centrosome separation after DNA damage. Constitutively active Plk1 overrides the inhibition of...

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PMID: 16157594
DOI: 10.1074/jbc.M505450200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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