Article
Association studies of cholesterol metabolism genes (CH25H, ABCA1 and CH24H) in Alzheimer's disease.
Neuroscience letters - 2 Jan 2006
Shibata Nobuto, Kawarai Toshitaka, Lee Joseph H, Lee Hye-Seung, Shibata Eri, Sato Christine, Liang Yan, Duara Rajan, Mayeux Richard P, St George-Hyslop Peter H, Rogaeva Ekaterina
Abstract excerpt
Recent studies have demonstrated that cholesterol metabolism has an important role in Alzheimer's disease (AD) pathogenesis, suggesting that cholesterol-related genes may be significant genetic risk factors for AD. Based on the results of genome-wide screens, along with biological studies, we selected three genes as candidates for AD risk factors: ATP-binding cassette transporter A1 (ABCA1), cholesterol...
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