Cholesterol 25-hydroxylase on chromosome 10q is a susceptibility gene for sporadic Alzheimer's disease.

doi:10.1159/000090362

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Article

Cholesterol 25-hydroxylase on chromosome 10q is a susceptibility gene for sporadic Alzheimer's disease.

Neuro-degenerative diseases - 1 Jan 2005

Papassotiropoulos Andreas, Lambert Jean-Charles, Wavrant-De Vrièze Fabienne, Wollmer M Axel, von der Kammer Heinz, Streffer Johannes R, Maddalena Alessia, Huynh Kim-Dung, Wolleb Sibylle, Lutjohann Dieter, Schneider Brigitte, Thal Dietmar R, Grimaldi Luigi M E, Tsolaki Magdalini, Kapaki Elisabeth, Ravid Rivka, Konietzko Uwe, Hegi Thomas, Pasch Thomas, Jung Hans, Braak Heiko, Amouyel Philippe, Rogaev Evgeny I, Hardy John, Hock Christoph, Nitsch Roger M

Abstract excerpt

Alzheimer's disease (AD) is the most common cause of dementia. It is characterized by beta-amyloid (A beta) plaques, neurofibrillary tangles and the degeneration of specifically vulnerable brain neurons. We observed high expression of the cholesterol 25-hydroxylase (CH25H) gene in specifically vulnerable brain regions of AD patients. CH25H maps to a region within 10q23 that has been previously linked to sporadic...

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PMID: 16909003
DOI: 10.1159/000090362

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