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Article

Stratified case sampling and the use of family controls.

Genetic epidemiology - 1 Apr 2001

Siegmund K D, Langholz B

Abstract excerpt

We compare the asymptotic relative efficiency (ARE) of different study designs for estimating gene and gene-environment interaction effects using matched case-control data. In the sampling schemes considered, cases are selected differentially based on their family history of disease. Controls are selected either from unrelated subjects or from among the case's unaffected siblings and cousins. Parameters are...

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PMID: 11255241
DOI: 10.1002/gepi.3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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