Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The CYP1A2-164A-->C polymorphism (CYP1A2*1F) is associated with the risk for colorectal adenomas in humans.

Cancer letters - 8 Nov 2005

Moonen Harald, Engels Leopold, Kleinjans Jos, Kok Theo de

Abstract excerpt

Colorectal cancer (CRC) is believed to be related to the intake of processed meat and the formed heterocyclic aromatic amines (HCA) herein, which are metabolically activated by the enzymes cytochrome P4501A2 (CYP1A2) and N-acetyltransferase 2 (NAT2). The influence of genotypic and phenotypic variations for CYP1A2 and NAT2 on the risk for colorectal adenomas was investigated in 94 individuals at different risk of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adenoma
Share to Aged, 80 and over
Share to Arylamine N-Acetyltransferase

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Case-Control Studies

Share to Colorectal Neoplasms

Share to Cytochrome P-450 CYP1A2

Share to Polymorphism, Genetic

Share to Risk Factors

Source

Identifiers

PMID: 16157215
DOI: 10.1016/j.canlet.2004.12.010

Genes

NAT2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The CYP1A2-164A-->C polymorphism (CYP1A2*1F) is associated with the risk for colorectal adenomas in humans.PMID 16157215Read ↗

Genetic variation in the bioactivation pathway for polycyclic hydrocarbons and heterocyclic amines in relation to risk of colorectal neoplasia.Semantic proximity Read ↗

A comprehensive analysis of phase I and phase II metabolism gene polymorphisms and risk of colorectal cancer.Semantic proximity Read ↗

CYP1A2 164 A-->C polymorphism, cigarette smoking, consumption of well-done red meat and risk of developing colorectal adenomas and carcinomas.Semantic proximity Read ↗

Polymorphisms of cytochrome P450 1A2 and N-acetyltransferase genes, meat consumption, and risk of colorectal cancer.Semantic proximity Read ↗

Association between the CYP1A2-164 A/C polymorphism and colorectal cancer susceptibility: a meta-analysis.Semantic proximity Read ↗

quantitative assessment of the influence of cytochrome P450 1A2 gene polymorphism and colorectal cancer risk.Semantic proximity Read ↗

Polymorphisms of xenobiotic-metabolizing genes and colorectal cancer risk in patients with lynch syndrome: A retrospective cohort study in Taiwan.Semantic proximity Read ↗

The CYP1A1 genotype may alter the association of meat consumption patterns and preparation with the risk of colorectal cancer in men and women.Semantic proximity Read ↗

[Heterocyclic aromatic amines, food-derived mutagens: metabolism and relevance to cancer susceptibility].Semantic proximity Read ↗

Genetic polymorphisms in heterocyclic amine metabolism and risk of colorectal adenomas.Semantic proximity Read ↗

Meat intake, heterocyclic amine exposure, and metabolizing enzyme polymorphisms in relation to colorectal polyp risk.Semantic proximity Read ↗

N-acetyltransferase 1 in colon and rectal cancer cases from an industrialized area.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.