Article
Who takes the lead in the development of ulcerative colitis-associated colorectal cancers: mutator, suppressor, or methylator pathway?
Cancer genetics and cytogenetics - 1 Oct 2005
Maia Lara, Dinis Joana, Cravo Marília, Claro Isabel, Baltazar Célia, Fonseca Isabel, Veloso Tavarela, Capelinha Ana F, Carneiro Fátima, Nobre-Leitão Carlos
Abstract excerpt
Although several genetic alterations have been identified in patients with ulcerative colitis (UC), it remains unclear whether these changes indicate an increased risk for malignancy. This paper analyzes the involvement of suppressor, mutator, and methylator pathways in malignant transformation associated with UC. A total of 60 colonic samples (47 affected non-neoplastic mucosa, 7 dysplasia, and 6 carcinoma) from...
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