Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

MYH biallelic mutation can inactivate the two genetic pathways of colorectal cancer by APC or MLH1 transversions.

Familial cancer - 1 Dec 2010

Lefevre Jérémie H, Colas Chrystelle, Coulet Florence, Bonilla Carolina, Mourra Najat, Flejou Jean-Francois, Tiret Emmanuel, Bodmer Walter, Soubrier Florent, Parc Yann

Abstract excerpt

MYH associated polyposis is a hereditary syndrome responsible for early colorectal cancer with a distinct genetic pathway from the Familial Adenomatous Polyposis or the Hereditary Non Polyposis Colorectal Cancer syndrome. We have studied a family with three members bearing a biallelic mutation in...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adaptor Proteins, Signal Transducing
Share to Adenoma
Share to Adenomatous Polyposis Coli

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA Glycosylases

Share to DNA, Neoplasm

Share to Genes, APC

Share to Microsatellite Instability

Share to MutL Protein Homolog 1

Source

Identifiers

PMID: 20640893
DOI: 10.1007/s10689-010-9367-0

Genes

MLH1
APC
KRAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20640893-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

MYH biallelic mutation can inactivate the two genetic pathways of colorectal cancer by APC or MLH1 transversions.PMID 20640893Read ↗

Implication of MYH in Colorectal PolyposisSemantic proximity Read ↗

Similar colorectal cancer risk in patients with monoallelic and biallelic mutations in the MYH gene identified in a population with adenomatous polyposis.Semantic proximity Read ↗

The role of MYH and microsatellite instability in the development of sporadic colorectal cancerSemantic proximity Read ↗

Prevalence of MYH germline mutations in Swiss APC mutation-negative polyposis patients.Semantic proximity Read ↗

Colorectal adenomatous polyposis Associated with MYH mutations: genotype and phenotype characteristics.Semantic proximity Read ↗

Is prophylactic colectomy indicated in patients with MYH-associated polyposis?Semantic proximity Read ↗

Exposing the MYtH about base excision repair and human inherited disease.Semantic proximity Read ↗

Autosomal recessive colorectal adenomatous polyposis due to inherited mutations of MYH.Semantic proximity Read ↗

Microsatellite stable colorectal cancers in clinically suspected hereditary nonpolyposis colorectal cancer patients without vertical transmission of disease are unlikely to be caused by biallelic germline mutations in MYH.Semantic proximity Read ↗

Multiple Colorectal Adenomas, Classic Adenomatous Polyposis, and Germ-Line Mutations in<i>MYH</i>Semantic proximity Read ↗

The multiple colorectal adenoma phenotype and MYH, a base excision repair gene.Semantic proximity Read ↗

Germline MUTYH (MYH) mutations in Portuguese individuals with multiple colorectal adenomas.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.