Evidence for a common biological pathway linking three Parkinson's disease‐causing genes: <i>parkin</i>,<i> PINK1</i> and <i>DJ‐1</i>

Abstract excerpt

Parkinson's disease (PD) is characterised by the loss of dopaminergic neurons in the midbrain. Autosomal recessive, early-onset cases of PD are predominantly caused by mutations in the parkin, PINK1 and DJ-1 genes. Animal and cellular models have verified a direct link between parkin and PINK1, whereby PINK1 phosphorylates and activates parkin at the outer mitochondrial membrane, resulting in removal of...

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