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Article

Lem3p is essential for the uptake and potency of alkylphosphocholine drugs, edelfosine and miltefosine.

The Journal of biological chemistry - 19 Sept 2003

Hanson Pamela K, Malone Lynn, Birchmore Jennifer L, Nichols J Wylie

Abstract excerpt

The alkylphosphocholine class of drugs, including edelfosine and miltefosine, has recently shown promise in the treatment of protozoal and fungal diseases, most notably, leishmaniasis. One of the major barriers to successful treatment of these infections is the development of drug resistance. To understand better the mechanisms underlying the development of drug resistance, we performed a combined mutant...

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PMID: 12842877
DOI: 10.1074/jbc.M305263200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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