Article
Differentiation-inducing factor-1 induces cyclin D1 degradation through the phosphorylation of Thr286 in squamous cell carcinoma.
Experimental cell research - 1 Nov 2005
Mori Jun, Takahashi-Yanaga Fumi, Miwa Yoshikazu, Watanabe Yutaka, Hirata Masato, Morimoto Sachio, Shirasuna Kanemitsu, Sasaguri Toshiyuki
Abstract excerpt
Differentiation-inducing factors (DIFs) are morphogens which induce cell differentiation in Dictyostelium. We reported that DIF-1 and DIF-3 inhibit proliferation and induce differentiation in mammalian cells. In this study, we investigated the effect of DIF-1 on oral squamous cell carcinoma cell lines NA and SAS, well differentiated and poorly differentiated cell lines, respectively. Although DIF-1 did not induce...
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