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Article

Sphingosine kinase regulates the sensitivity of Dictyostelium discoideum cells to the anticancer drug cisplatin.

Eukaryotic cell - 1 Jan 2005

Min Junxia, Traynor David, Stegner Andrew L, Zhang Lei, Hanigan Marie H, Alexander Hannah, Alexander Stephen

Abstract excerpt

The drug cisplatin is widely used to treat a number of tumor types. However, resistance to the drug, which remains poorly understood, limits its usefulness. Previous work using Dictyostelium discoideum as a model for studying drug resistance showed that mutants lacking sphingosine-1-phosphate (S-1-P) lyase, the enzyme that degrades S-1-P, had increased resistance to cisplatin, whereas mutants overexpressing the...

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Identifiers

PMID: 15643073
DOI: 10.1128/EC.4.1.178-189.2005
PMCID: PMC544159

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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