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Differentiation-inducing factor-3 inhibits intestinal tumor growth in vitro and in vivo

1 Apr 2015

Abstract excerpt

Differentiation-inducing factor-1 (DIF-1) produced by Dictyostelium discoideum strongly inhibits the proliferation of various types of cancer cells by suppression of the Wnt/β-catenin signal transduction pathway. In the present study, we examined the effect of differentiation-inducing factor-3 (DIF-3), a monochlorinated metabolite of DIF-1 that is also produced by D. discoideum, on human colon cancer cell lines...

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PMID: 25913757
DOI: 10.1016/j.jphs.2015.03.005

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