Article
The amino-terminal non-catalytic region of Salmonella typhimurium SigD affects actin organization in yeast and mammalian cells.
Cellular microbiology - 1 Oct 2005
Alemán Ainel, Rodríguez-Escudero Isabel, Mallo Gustavo V, Cid Víctor J, Molina María, Rotger Rafael
Abstract excerpt
The internalization of Salmonella into epithelial cells relies on the function of bacterial proteins which are injected into the cell by a specialized type III secretion system. Such bacterial effectors interfere with host cell signalling and induce local cytoskeletal rearrangements. One of such effectors is SigD/SopB, which shares homology with mammalian inositol phosphatases. We made use of the Saccharomyces...
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