Article
A protein critical for a Theiler's virus-induced immune system-mediated demyelinating disease has a cell type-specific antiapoptotic effect and a key role in virus persistence.
Journal of virology - 1 Nov 1998
Ghadge G D, Ma L, Sato S, Kim J, Roos R P
Abstract excerpt
TO subgroup strains of Theiler's murine encephalomyelitis virus (TMEV) induce a persistent central nervous system infection and demyelinating disease in mice. This disease serves as an experimental model of multiple sclerosis (MS) because the two diseases have similar inflammatory white matter pa...
Topics
- Animals
- Apoptosis
- Cell Line
- Central Nervous System
- Cricetinae
- Demyelinating Diseases
- Disease Models, Animal
- Humans
- Immune System
- Mice
- Multiple Sclerosis
- Mutation
- Poliomyelitis
- Protein Biosynthesis
- T-Lymphocytes, Cytotoxic