Article
Viral mouse models of multiple sclerosis and epilepsy: Marked differences in neuropathogenesis following infection with two naturally occurring variants of Theiler's virus BeAn strain.
Neurobiology of disease - 1 Mar 2017
Bröer Sonja, Hage Elias, Käufer Christopher, Gerhauser Ingo, Anjum Muneeb, Li Lin, Baumgärtner Wolfgang, Schulz Thomas F, Löscher Wolfgang
Abstract excerpt
Following intracerebral inoculation, the BeAn 8386 strain of Theiler's virus causes persistent infection and inflammatory demyelinating encephalomyelitis in the spinal cord of T-cell defective SJL/J mice, which is widely used as a model of multiple sclerosis. In contrast, C57BL/6 (B6) mice clear the virus and develop inflammation and lesions in the hippocampus, associated with acute and chronic seizures,...
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