Article
Significant association of BDNF haplotypes in European-American male smokers but not in European-American female or African-American smokers.
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics - 5 Nov 2005
Beuten Joke, Ma Jennie Z, Payne Thomas J, Dupont Randolph T, Quezada Paulina, Huang Weihua, Crews Karen M, Li Ming D
Abstract excerpt
Brain-derived neurotrophic factor (BDNF) influences dopamine and serotonin neurotransmission in the brain, both of which are involved in the reward system of addiction. The BDNF gene is located in a genomic region on chromosome 11p where we and others have found 'significant' linkage to nicotine dependence (ND). We tested the potential role of variants within BDNF in vulnerability to ND, which was assessed by...
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