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Article

Confirmation of association between the Val66Met polymorphism in the brain-derived neurotrophic factor (BDNF) gene and bipolar I disorder.

American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics - 5 Nov 2005

Lohoff F W, Sander T, Ferraro T N, Dahl J P, Gallinat J, Berrettini W H

Abstract excerpt

Recent studies have indicated that the brain-derived neurotrophic factor (BDNF) gene is involved in the etiology of bipolar disorder (BPD). Two family-based association studies showed that the Val allele of the functional polymorphism Val66Met in the BDNF gene is associated with BPD; however, others could not confirm the results. Here we performed a replication study in an independent sample and tested the...

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Source

Identifiers

PMID: 16152572
DOI: 10.1002/ajmg.b.30215

Genes

BDNF
BPI

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Confirmation of association between the Val66Met polymorphism in the brain-derived neurotrophic factor (BDNF) gene and bipolar I disorder.PMID 16152572Read ↗

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Evidence of associations between bipolar disorder and the brain-derived neurotrophic factor (BDNF) gene.Semantic proximity Read ↗

Genetics of bipolar disorder: focus on BDNF Val66Met polymorphism.Semantic proximity Read ↗

The brain-derived neurotrophic factor gene confers susceptibility to bipolar disorder: evidence from a family-based association study.Semantic proximity Read ↗

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