Article
Positive association between the brain-derived neurotrophic factor (BDNF) gene and bipolar disorder in the Han Chinese population.
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics - 5 Jan 2010
Xu Jie, Liu Yun, Wang Peng, Li Sheng, Wang Yabing, Li Jun, Zhou Daizhan, Chen Zhuo, Zhao Teng, Wang Ting, Xu He, Yang Yifeng, Feng Guoyin, He Lin, Yu Lan
Abstract excerpt
Brain-derived neurotrophic factor (BDNF) is the most widely distributed neurotrophin in the central nervous system (CNS), and services many biological functions such as neural survival, differentiation, and plasticity. Previous studies have suggested that the Val66Met (also known as rs6265 or G196A) variant of BDNF is associated with bipolar disorder (BPD), but the results have been inconclusive. We therefore...
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