Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Integration Profile and Safety of an Adenovirus Hybrid-Vector Utilizing Hyperactive Sleeping Beauty Transposase for Somatic Integration

4 Oct 2013

Abstract excerpt

We recently developed adenovirus/transposase hybrid-vectors utilizing the previously described hyperactive Sleeping Beauty (SB) transposase HSB5 for somatic integration and we could show stabilized transgene expression in mice and a canine model for hemophilia B. However, the safety profile of these hybrid-vectors with respect to vector dose and genotoxicity remains to be investigated. Herein, we evaluated this...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to CAR-T cell therapy research
Share to CRISPR and Genetic Engineering
Share to Virus-based gene therapy research

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 24124483
DOI: 10.1371/journal.pone.0075344

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Integration Profile and Safety of an Adenovirus Hybrid-Vector Utilizing Hyperactive Sleeping Beauty Transposase for Somatic IntegrationPMID 24124483Read ↗

Hyperactive sleeping beauty transposase enables persistent phenotypic correction in mice and a canine model for hemophilia B.Semantic proximity Read ↗

Going non-viral: theSleeping Beautytransposon system breaks on through to the clinical sideSemantic proximity Read ↗

Sleeping Beauty Vector System Moves Toward Human Trials in the United StatesSemantic proximity Read ↗

Hyperactive transposase mutants of the Sleeping Beauty transposon.Semantic proximity Read ↗

Nonviral Gene Delivery with the <i>Sleeping Beauty</i> Transposon SystemSemantic proximity Read ↗

Medicinal Products Based on Adeno-Associated Viral Vectors: A Regulatory Perspective on the Potential Risk of Insertion-Mediated TumorigenesisSemantic proximity Read ↗

Development of the hybrid Sleeping Beauty-baculovirus vector for sustained gene expression and cancer therapySemantic proximity Read ↗

Gene Therapy with the Sleeping Beauty Transposon SystemSemantic proximity Read ↗

Evaluating the state of the science for adeno-associated virus integration: An integrated perspectiveSemantic proximity Read ↗

Comparison of Lentiviral and Sleeping Beauty Mediated αβ T Cell Receptor Gene TransferSemantic proximity Read ↗

Large-Scale Analysis of Adeno-Associated Virus Vector Integration Sites in Normal Human CellsSemantic proximity Read ↗

RNA-guided Retargeting of <i>Sleeping Beauty</i> Transposition in Human CellsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.