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Article

Hyperactive sleeping beauty transposase enables persistent phenotypic correction in mice and a canine model for hemophilia B.

Molecular therapy : the journal of the American Society of Gene Therapy - 1 Nov 2010

Hausl Martin A, Zhang Wenli, Müther Nadine, Rauschhuber Christina, Franck Helen G, Merricks Elizabeth P, Nichols Timothy C, Kay Mark A, Ehrhardt Anja

Abstract excerpt

Sleeping Beauty (SB) transposase enables somatic integration of exogenous DNA in mammalian cells, but potency as a gene transfer vector especially in large mammals has been lacking. Herein, we show that hyperactive transposase system delivered by high-capacity adenoviral vectors (HC-AdVs) can res...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 20717103
DOI: 10.1038/mt.2010.169
PMCID: PMC2990515

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20717103-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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