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Article

Novel 'inflammatory plaque' pathology in presenilin-1 Alzheimer's disease.

Neuropathology and applied neurobiology - 1 Oct 2005

Shepherd C E, Gregory G C, Vickers J C, Halliday G M

Abstract excerpt

Inflammation, in the form of reactive astrocytes and microglia, is thought to play an important role in Alzheimer's disease (AD) pathogenesis where it correlates with brain atrophy and disease severity. The Abeta protein, which comprises senile plaques, is thought to be responsible for initiating this inflammatory response. Despite having a more aggressive disease process and greater Abeta deposition, few studies...

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Source

Identifiers

PMID: 16150121
DOI: 10.1111/j.1365-2990.2005.00667.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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