Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Fast and slow metabolizers of Hoasca.

Journal of psychoactive drugs - 1 Jun 2005

Callaway J C

Abstract excerpt

Harmine, a major alkaloid in ayahuasca (hoasca), is a selective and reversible inhibitor of the enzyme monoamine oxidase-A (MAO-A). It is also a selective inhibitor of the human cytochrome P450 isozyme 2D6 (CYP 2D6), which metabolizes harmine to a more hydrophilic derivative for eventual excretion. CYP 2D6 exhibits a wide range of polymorphisms in human populations, and variations in this enzymatic activity could...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Area Under Curve
Share to Cytochrome P-450 CYP2D6
Share to Phenotype

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Plant Extracts

Share to Plants

Share to Time Factors

Source

Identifiers

PMID: 16149329
DOI: 10.1080/02791072.2005.10399797

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 11 closest

Fast and slow metabolizers of Hoasca.PMID 16149329Read ↗

Effects of Khat (Catha edulis) use on catalytic activities of major drug-metabolizing cytochrome P450 enzymes and implication of pharmacogenetic variations.Semantic proximity Read ↗

CYP2D6 phenotype explains reported yohimbine concentrations in four severe acute intoxications.Semantic proximity Read ↗

Prevalence of desloratadine poor metabolizer phenotype in healthy Jordanian males.Semantic proximity Read ↗

Primary and secondary oxidative metabolism of dextromethorphan. In vitro studies with female Sprague-Dawley and Dark Agouti rat liver microsomes.Semantic proximity Read ↗

Effects of CYP2D6 status on harmaline metabolism, pharmacokinetics and pharmacodynamics, and a pharmacogenetics-based pharmacokinetic model.Semantic proximity Read ↗

[Human biodiversity and its effects on the pharmacological variability: CYP2D6 and NAT2 enzymes in Amerind populations of Panama, Colombia and Costa Rica].Semantic proximity Read ↗

In vivo effects of goldenseal, kava kava, black cohosh, and valerian on human cytochrome P450 1A2, 2D6, 2E1, and 3A4/5 phenotypes.Semantic proximity Read ↗

Disposition of lupanine and 13-hydroxylupanine in man.Semantic proximity Read ↗

Psychedelic Therapy: A Primer for Primary Care Clinicians – Part III. N,N-dimethyltryptamine (DMT) and AyahuascaSemantic proximity Read ↗

Enzyme polymorphism on the metabolic O-demethylation of dextromethorphan in a South American population.Semantic proximity Read ↗

A herbal-drug interaction study of keishi-bukuryo-gan, a traditional herbal preparation used for menopausal symptoms, in healthy female volunteers.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.