Disposition of lupanine and 13-hydroxylupanine in man.

doi:10.3109/00498259409043291

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Article

Disposition of lupanine and 13-hydroxylupanine in man.

Xenobiotica; the fate of foreign compounds in biological systems - 1 Sept 1994

Petterson D S, Greirson B N, Allen D G, Harris D J, Power B M, Dusci L J, Ilett K F

Abstract excerpt

1. The in vivo disposition of lupanine and 13-hydroxylupanine was studied in subjects identified as poor metabolizers (PM, n = 4) and extensive metabolizers (EM, n = 7) phenotypes for cytochrome P4502D6 (CYP2D6). 2. After oral administration (40.26 mumol), the half-life (t1/2) of lupanine determi...

Topics

Alkaloids
Blood Cell Count
Blood Chemical Analysis
Blood Pressure
Flame Ionization
Gas Chromatography-Mass Spectrometry
Heart Rate
Humans
Phenotype
Sparteine

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