Article
High-resolution crystal structures of villin headpiece and mutants with reduced F-actin binding activity.
Biochemistry - 13 Sept 2005
Meng Jianmin, Vardar Didem, Wang Yeming, Guo Hwai-Chen, Head James F, McKnight C James
Abstract excerpt
Villin-type headpiece domains are approximately 70 amino acid modular motifs found at the C terminus of a variety of actin cytoskeleton-associated proteins. The headpiece domain of villin, a protein found in the actin bundles of the brush border epithelium, is of interest both as a compact F-actin binding domain and as a model folded protein. We have determined the high-resolution crystal structures of chicken...
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