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Article

The fast-folding HP35 double mutant has a substantially reduced primary folding free energy barrier.

The Journal of chemical physics - 21 Oct 2008

Lei Hongxing, Deng Xiaojian, Wang Zhixiang, Duan Yong

Abstract excerpt

The LYS24/29NLE double mutant of villin headpiece subdomain (HP35) is the fastest folding protein known so far with a folding time constant of 0.6 micros. In this work, the folding mechanism of the mutant has been investigated by both conventional and replica exchange molecular dynamics (CMD and REMD) simulations with AMBER FF03 force field and a generalized-Born solvation model. Direct comparison to the ab...

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Identifiers

PMID: 19045234
DOI: 10.1063/1.2995987
PMCID: PMC2671186

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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