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Article

Identification of the PXW sequence as a structural gatekeeper of the headpiece C-terminal subdomain fold.

Journal of molecular biology - 23 Jun 2006

Vermeulen Wim, Van Troys Marleen, Bourry David, Dewitte Daisy, Rossenu Stefaan, Goethals Marc, Borremans Frans A M, Vandekerckhove Joël, Martins José C, Ampe Christophe

Abstract excerpt

The HeadPiece (HP) domain, present in several F-actin-binding multi-domain proteins, features a well-conserved, solvent-exposed PXWK motif in its C-terminal subdomain. The latter is an autonomously folding subunit comprised of three alpha-helices organised around a hydrophobic core, with the sequence motif preceding the last helix. We report the contributions of each conserved residue in the PXWK motif to human...

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Identifiers

PMID: 16697408
DOI: 10.1016/j.jmb.2006.04.042

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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