Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The methionine synthase polymorphism c.2756Aright curved arrow G (D919G) is relevant for disease-free longevity.

International journal of molecular medicine - 1 Oct 2005

Linnebank Michael, Fliessbach Klaus, Kolsch Heike, Rietschel Marcella, Wullner Ullrich

Abstract excerpt

The functional polymorphism methionine synthase (MTR) c.2576A-->G (D919G) influences homocysteine and folate metabolism and has been reported to be of protective function against oncological, neurodegenerative and vascular diseases. We analyzed 329 healthy individuals to confirm whether this polymorphism might be of epidemiological impact on disease-free longevity. In our sample, prevalence of the G-allele was...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase
Share to Adolescent

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Age Factors

Share to Aged, 80 and over

Share to Gene Frequency

Share to Longevity

Share to Polymorphism, Genetic

Share to Sex Factors

Source

Identifiers

PMID: 16142417

Genes

MTR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The methionine synthase polymorphism c.2756Aright curved arrow G (D919G) is relevant for disease-free longevity.PMID 16142417Read ↗

The Implication of a Polymorphism in the Methylenetetrahydrofolate Reductase Gene in Homocysteine Metabolism and Related Civilisation DiseasesSemantic proximity Read ↗

Methylenetetrahydrofolate (MTHFR), the One-Carbon Cycle, and Cardiovascular RisksSemantic proximity Read ↗

A common methylenetetrahydrofolate reductase gene mutation and longevity.Semantic proximity Read ↗

Genetic variants of methionine metabolism and DNA methylation.Semantic proximity Read ↗

The SNP Rs915014 in MTHFR Regulated by MiRNA Associates with Atherosclerosis.Semantic proximity Read ↗

Folate network genetic variation predicts cardiovascular disease risk in non-Hispanic white males.Semantic proximity Read ↗

Distinguishing between longevity and buffered-deleterious genotypes for exceptional human longevity: the case of the MTP gene.Semantic proximity Read ↗

Genetic variants of homocysteine metabolism and multiple sclerosis: a case-control study.Semantic proximity Read ↗

Effect of heterozygosity for the methionine synthase 2756 A-->G mutation on the risk for recurrent cardiovascular events.Semantic proximity Read ↗

Methionine synthase D919G polymorphism is a significant but modest determinant of circulating homocysteine concentrations.Semantic proximity Read ↗

The 2756A>G variant in the gene encoding methionine synthase: its relation with plasma homocysteine levels and risk of coronary heart disease in a Dutch case-control study.Semantic proximity Read ↗

The 1316T>C missenses mutation in MTHFR contributes to MTHFR deficiency by targeting MTHFR to proteasome degradation.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.