Article
The 2756A>G variant in the gene encoding methionine synthase: its relation with plasma homocysteine levels and risk of coronary heart disease in a Dutch case-control study.
Thrombosis research - 1 May 2003
Klerk Mariska, Lievers Karin J A, Kluijtmans Leo A J, Blom Henk J, den Heijer Martin, Schouten Evert G, Kok Frans J, Verhoef Petra
Abstract excerpt
INTRODUCTION: Elevated plasma homocysteine levels have been associated with increased risk of cardiovascular disease. A 2756A>G polymorphism has been found in the gene (MTR) coding for methionine synthase, an enzyme catalyzing remethylation of homocysteine to methionine. MATERIALS AND METHODS: In a Dutch case-control study comprising 123 cases with coronary heart disease (CHD) and 540 controls, we evaluated...
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