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Article

Sipa1 is a candidate for underlying the metastasis efficiency modifier locus Mtes1.

Nature genetics - 1 Oct 2005

Park Yeong-Gwan, Zhao Xiaohong, Lesueur Fabienne, Lowy Douglas R, Lancaster Mindy, Pharoah Paul, Qian Xiaolan, Hunter Kent W

Abstract excerpt

We previously identified loci in the mouse genome that substantially influence the metastatic efficiency of mammary tumors. Here, we present data supporting the idea that the signal transduction molecule, Sipa1, is a candidate for underlying the metastasis efficiency modifier locus Mtes1. Analysis of candidate genes identified a nonsynonymous amino acid polymorphism in Sipa1 that affects the Sipa1 Rap-GAP...

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Identifiers

PMID: 16142231
DOI: 10.1038/ng1635
PMCID: PMC2140048

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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