Article
Association of N-acetyl transferase 2 gene polymorphism and slow acetylator phenotype with young onset and late onset Parkinson's disease among Indians.
Pharmacogenetics and genomics - 1 Oct 2005
Chaudhary Shashi, Behari Madhuri, Dihana Maninder, Swaminath Pazhayannur V, Govindappa Shyla T, Jayaram Sachi, Singh Sumit, Muthane Uday B, Juyal Ramesh C, B K Thelma
Abstract excerpt
OBJECTIVES: To investigate the association of (i) seven SNPs and SNP haplotypes in the phase II conjugating enzyme N-acetyl transferase 2 gene; and (ii) slow acetylator phenotype, with the development of young onset (YO) and late onset (LO) Parkinson's disease (PD) among Indians. METHODS: A total of 267 cases (132 YOPD, age at onset < or =40 years; 135 LOPD, age at onset >40 years) and 324 age and sex matched...
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