Article
Detailed genotyping demonstrates association between the slow acetylator genotype for N-acetyltransferase 2 (NAT2) and familial Parkinson's disease.
Movement disorders : official journal of the Movement Disorder Society - 1 Jan 2000
Bandmann O, Vaughan J R, Holmans P, Marsden C D, Wood N W
Abstract excerpt
In a preliminary report we demonstrated an association between the slow acetylator genotype of N-acetyltransferase 2 (NAT2) and familial cases of Parkinson's disease (FPD). Using a considerably more precise NAT2 typing method, which detects all mutant NAT2 alleles with a frequency of >1% in the white population, we have now retyped all the original patients and control subjects to investigate the reliability of...
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