Article
Slow allotypic variants of the NAT2 gene and susceptibility to early-onset Parkinson's disease.
Neurology - 1 Dec 1998
Agúndez J A, Jiménez-Jiménez F J, Luengo A, Molina J A, Ortí-Pareja M, Vázquez A, Ramos F, Duarte J, Coria F, Ladero J M, Alvarez-Cermeño J C, Benítez J
Abstract excerpt
OBJECTIVE: To determine the frequency and the linkage distribution of seven mutations at the polymorphic gene coding for the arylamine N-acetyl transferase (NAT2; EC 2.3.1.5) in 121 unrelated patients with sporadic PD and in 121 unrelated healthy volunteers. METHODS: The study was performed with mutation-specific PCR using genomic DNA obtained from blood of the probands. RESULTS: Comparison of the NAT2 genotypes...
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