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Article

Phagocytic ability declines with age in adult Drosophila hemocytes.

Aging cell - 1 Aug 2014

Horn Lucas, Leips Jeff, Starz-Gaiano Michelle

Abstract excerpt

Most multicellular organisms show a physiological decline in immune function with age. However, little is known about the mechanisms underlying these changes. We examined Drosophila melanogaster, an important model for identifying genes affecting innate immunity and senescence, to explore the role of phagocytosis in age-related immune dysfunction. We characterized the localized response of immune cells at the...

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PMID: 24828474
DOI: 10.1111/acel.12227
PMCID: PMC4116448

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