Article
Deletion of XPC leads to lung tumors in mice and is associated with early events in human lung carcinogenesis.
Proceedings of the National Academy of Sciences of the United States of America - 13 Sept 2005
Hollander M Christine, Philburn Robyn T, Patterson Andrew D, Velasco-Miguel Susana, Friedberg Errol C, Linnoila R Ilona, Fornace Albert J
Abstract excerpt
Chromosome 3p and 1p deletions are among the most frequent genetic changes in human lung cancer and although candidate tumor suppressor genes have been identified in these regions, no causative correlations have been drawn between deletion or mutation of these and lung carcinogenesis. We identify XPC and Gadd45a as genes within each of these regions involved in lung tumor initiation and progression, respectively....
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