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Transgenic cyclin E triggers dysplasia and multiple pulmonary adenocarcinomas

27 Feb 2007

Abstract excerpt

Cyclin E is a critical G(1)-S cell cycle regulator aberrantly expressed in bronchial premalignancy and lung cancer. Cyclin E expression negatively affects lung cancer prognosis. Its role in lung carcinogenesis was explored. Retroviral cyclin E transduction promoted pulmonary epithelial cell growth, and small interfering RNA targeting of cyclin E repressed this growth. Murine transgenic lines were engineered to...

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PMID: 17360482
DOI: 10.1073/pnas.0606537104

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