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Article

Therapeutic Silencing of MicroRNA-122 in Primates with Chronic Hepatitis C Virus Infection

3 Dec 2009

Abstract excerpt

The liver-expressed microRNA-122 (miR-122) is essential for hepatitis C virus (HCV) RNA accumulation in cultured liver cells, but its potential as a target for antiviral intervention has not been assessed. We found that treatment of chronically infected chimpanzees with a locked nucleic acid (LNA)-modified oligonucleotide (SPC3649) complementary to miR-122 leads to long-lasting suppression of HCV viremia, with no...

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PMID: 19965718
DOI: 10.1126/science.1178178

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